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Posted: December 08, 2017

Canola oil linked to dementia, study says

David McNew/Getty Images

By Najja Parker, The Atlanta Journal-Constitution

Memory loss and confusion are common symptoms of dementia. Now scientists are linking canola oil to the disease in a new report

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Researchers from Temple University recently conducted an experiment, published in Scientific Reports, to determine how the common cooking oil may have an effect on the brain.

To do so, they examined mice that were six months old, dividing them into two groups. One was fed a normal diet, while the other had “a diet supplemented with the equivalent of about two tablespoons of canola oil,” the authors explained. 

After observing the animals for 12 months, they weighed them. They found that the mice on the canola oil diet weighed significantly more than those on a regular diet. 

They then assessed their working memory, short-term memory and learning ability by administering maze tests. They discovered the mice that had consumed canola oil suffered damage to their working memory. The canola oil-treated mice had reduced levels of amyloid beta 1-40, a protein that serves a beneficial role in the brain. 

“As a result of decreased amyloid beta 1-40, animals on the canola oil diet further showed increased formation of amyloid plaques in the brain, with neurons engulfed in amyloid beta 1-42,” the authors said. “The damage was accompanied by a significant decrease in the number of contacts between neurons, indicative of extensive synapse injury. Synapses, the areas where neurons come into contact with one another, play a central role in memory formation and retrieval.”

Their findings suggest canola oil is not beneficial to the brain, especially when it is consumed over long periods of time. Researchers now hope to further their studies to find out exactly how much canola oil can produce changes in the brain and if it can be linked to Alzheimer’s disease. 

“Even though canola oil is a vegetable oil, we need to be careful before we say that it is healthy,” lead researcher Domenico Pratico said. “Based on the evidence from this study, canola oil should not be thought of as being equivalent to oils with proven health benefits.”


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